Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex
- Messori, L.
- Casini, Angela
- Gabbiani, C.
- Michelucci, E.
- Cubo, L.
- Ríos-Luci, C.
- Padrón, J. M.
- Navarro-Ranninger, C.
- Quiroga, A. G.
DOIAbstract
Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides
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